CIAP2 Inhibits Anigen Receptor Signaling by Targeting Bcl10 for Degredation

MiR-125b inhibits stromal cell proliferation in giant cell tumor of bone by targeting parathyroid hormone 1 receptor

Objective(s):miR-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (GCT) of bone remains poorly understood. The current study aimed to investigate the potential role and mechanism of miR-125b in GCT. Materials and Methods:Expression levels of miR-125b in GCT tissues were determined using RT-PCR. The cell proliferation was surveyed by direct cell coun...

Targeting fibroblast growth factor receptor signaling inhibits prostate cancer progression.

PURPOSE Extensive correlative studies in human prostate cancer as well as studies in vitro and in mouse models indicate that fibroblast growth factor receptor (FGFR) signaling plays an important role in prostate cancer progression. In this study, we used a probe compound for an FGFR inhibitor, which potently inhibits FGFR-1-3 and significantly inhibits FGFR-4. The purpose of this study is to de...

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas.

The pathogenesis of mucosa-associated lymphoid tissue (MALT) lymphomas is associated with independent chromosomal translocations that lead to the upregulation of either BCL10 or MALT1 or the generation of a fusion protein, cIAP2-MALT1. While both BCL10 and MALT1 are critically involved in antigen receptor-mediated NF-kappaB activation, the role of cIAP2 is not clear. Here we show that cIAP2 is ...

miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor mRNA †

mir-125b inhibits stromal cell proliferation in giant cell tumor of bone by targeting parathyroid hormone 1 receptor

objective(s):mir-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (gct) of bone remains poorly understood. the current study aimed to investigate the potential role and mechanism of mir-125b in gct. materials and methods:expression levels of mir-125b in gct tissues were determined using rt-pcr. the cell proliferation was surveyed by direct cell coun...